Genomic DNA gains and losses can play a causal role in many diseases. Comparative genomic hybridization (CGH) is a powerful technique for the detection of chromosomal imbalances. CGH can also be used to identify different genes in diverse subtypes of the same species, thus indirectly confirming those phenotypes. The CGH method is based on a comparison of the test and control DNA samples which are labeled with different fluorophores, equally mixed, and simultaneously hybridized on one microarray, which can measure the DNA copy number differences between the test and control samples rapidly .
|
